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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
21/12/2018 |
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Actualizado : |
09/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
SLVEIRA, A. M.; NASCIMENTO, E. M.; KONRADT, G.; NETO, E. G. M.; DRIEMEIER, D.; GALIZA, J. N. G.; DANTAS, A. F. M.; RIET-CORREA, F. |
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Afiliación : |
ALINE M. SILVEIRA, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Brazil.; EDUARDO M. NASCIMENTO, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Brazil.; GUILHERME KONRADT, Setor de Patologia Veterinária, Hospital Veterinário, Universidade Federal Do Rio Grande Do sul (UFRGS), .; ELDINÊ G. MIRANDA NETO, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Brazil.; DAVID DRIEMEIER, Setor de Patologia Veterinária, Hospital Veterinário, Universidade Federal Do Rio Grande Do sul (UFRGS), Brazil.; GLAUCO JOSÉ N. GALIZA, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Brazil.; ANTONIO F.M. DANTAS, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Brazil.; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Tuberculosis of the central nervous system in cattle in Paraíba, Brazil. [Tuberculose no sistema nervoso central de bovinos na Paraíba.] |
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Fecha de publicación : |
2018 |
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Fuente / Imprenta : |
Pesquisa Veterinaria Brasileira 38(11):2099-2108, 1 November 2018. OPEN ACCESS |
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ISSN : |
0100-736X |
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DOI : |
10.1590/1678-5150-PVB-5976 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received on June 26, 2018. // Accepted for publication on July 12, 2018. |
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Contenido : |
ABSTRACT.
This paper describes six cases of tuberculosis in the central nervous system (CNS) of cattle in the state of Paraíba in northeastern Brazil. We reviewed the autopsy reports of 851 bovine necropsies performed from 2003 to 2016. Seventy-three (8.6%) cattle were diagnosed with tuberculosis and six showed lesions in the CNS. Three cases affected cattle up to two-year-old and other three affected adults. Three cattle presented exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical signs. At necropsy, five cattle had thickening of the leptomeninges of the cerebellum, pons, obex, spinal cord and cortex, mainly, in the region near the brain basilar Willis' circle. Another animal, presented a single focal lesion in the cerebellum. Microscopically we observed moderate to severe granulomatous meningitis and encephalitis. Five cattle presented lesions in the lungs and mediastinal lymph nodes and three of them had disseminated lesions in other organs. In all cattle acid-fast bacilli were observed in the lesions and marked positive for immunohistochemistry with polyclonal antibody anti-Mycobacterium tuberculosis. It is concluded that bovine tuberculosis of central nervous system occurs sporadically in Paraíba, in cattle of different ages, most of them with disseminate lesions in other organs. The location of the lesions suggests that the agent invaded the brain by hematogenous route through the circle of Willis.
© 2018 Colegio Brasileiro de Patologia Animal. All Rights Reserved.
RESUMO.
Descrevem-se seis casos de tuberculose no sistema nervoso central (SNC) em bovinos, no semiárido da Paraíba. Foram revisados os laudos de um total de 851 necropsias de bovinos realizadas no período de 2003 a 2016. Destes, 73 (8,6%) foram diagnosticados com tuberculose e seis apresentavam lesões no SNC. Três casos ocorreram em bovinos de até dois anos de idade e três em bovinos adultos. Três bovinos apresentaram exclusivamente sinais nervosos, dois tinham sinais respiratórios e perda de peso e um não apresentava nenhum sinal clínico. Macroscopicamente, em cinco bovinos, havia espessamento das leptomeninges do cerebelo, medula espinhal, ponte, obex, colículos e córtex, principalmente, na região basilar encefálica próxima ao polígono de Willis. Em apenas um bovino houve a presença de tubérculo único no cerebelo. Microscopicamente observou-se moderada a acentuada meningite e encefalite granulomatosa. Cinco bovinos apresentaram lesões pulmonares e nos gânglios mediastínicos e três deles tinham lesões disseminadas em outros órgãos. Em todos os bovinos foram encontrados bacilos ácido-álcool resistentes intralesionais e todos tiveram marcação positiva na técnica de imuno-histoquímica com anticorpo policlonal anti-Mycobacterium tuberculosis. Conclui‑se que a tuberculose do sistema nervoso central de bovinos ocorre de forma esporádica na Paraíba, principalmente em bovinos com lesões disseminadas em outros órgãos. Sugere-se que a disseminação do agente ocorre pela via hematógena, possivelmente através do polígono de Willis. MenosABSTRACT.
This paper describes six cases of tuberculosis in the central nervous system (CNS) of cattle in the state of Paraíba in northeastern Brazil. We reviewed the autopsy reports of 851 bovine necropsies performed from 2003 to 2016. Seventy-three (8.6%) cattle were diagnosed with tuberculosis and six showed lesions in the CNS. Three cases affected cattle up to two-year-old and other three affected adults. Three cattle presented exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical signs. At necropsy, five cattle had thickening of the leptomeninges of the cerebellum, pons, obex, spinal cord and cortex, mainly, in the region near the brain basilar Willis' circle. Another animal, presented a single focal lesion in the cerebellum. Microscopically we observed moderate to severe granulomatous meningitis and encephalitis. Five cattle presented lesions in the lungs and mediastinal lymph nodes and three of them had disseminated lesions in other organs. In all cattle acid-fast bacilli were observed in the lesions and marked positive for immunohistochemistry with polyclonal antibody anti-Mycobacterium tuberculosis. It is concluded that bovine tuberculosis of central nervous system occurs sporadically in Paraíba, in cattle of different ages, most of them with disseminate lesions in other organs. The location of the lesions suggests that the agent invaded the brain by hematogenous route through the circle of Willis.
© 2018 Colegio ... Presentar Todo |
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Palabras claves : |
ACID-FAST RESISTANT BACTERIA; BACTERIOSES; BRAZIL; CATTLE; CENTRAL NERVOUS SYSTEM; MYCOBACTERIUM SP; PARAIBA; PATHOLOGY; PLATAFORMA SALUD ANIMAL; TUBERCULOSIS; ZIEHL NEELSEN. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12209/1/27-11-2018-21-1512-pvbAO5976.pdf
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Marc : |
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001 1059376
005 2019-10-09
008 2018 bl uuuu u00u1 u #d
022 $a0100-736X
024 7 $a10.1590/1678-5150-PVB-5976$2DOI
100 1 $aSLVEIRA, A. M.
245 $aTuberculosis of the central nervous system in cattle in Paraíba, Brazil. [Tuberculose no sistema nervoso central de bovinos na Paraíba.]$h[electronic resource]
260 $c2018
500 $aArticle history: Received on June 26, 2018. // Accepted for publication on July 12, 2018.
520 $aABSTRACT. This paper describes six cases of tuberculosis in the central nervous system (CNS) of cattle in the state of Paraíba in northeastern Brazil. We reviewed the autopsy reports of 851 bovine necropsies performed from 2003 to 2016. Seventy-three (8.6%) cattle were diagnosed with tuberculosis and six showed lesions in the CNS. Three cases affected cattle up to two-year-old and other three affected adults. Three cattle presented exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical signs. At necropsy, five cattle had thickening of the leptomeninges of the cerebellum, pons, obex, spinal cord and cortex, mainly, in the region near the brain basilar Willis' circle. Another animal, presented a single focal lesion in the cerebellum. Microscopically we observed moderate to severe granulomatous meningitis and encephalitis. Five cattle presented lesions in the lungs and mediastinal lymph nodes and three of them had disseminated lesions in other organs. In all cattle acid-fast bacilli were observed in the lesions and marked positive for immunohistochemistry with polyclonal antibody anti-Mycobacterium tuberculosis. It is concluded that bovine tuberculosis of central nervous system occurs sporadically in Paraíba, in cattle of different ages, most of them with disseminate lesions in other organs. The location of the lesions suggests that the agent invaded the brain by hematogenous route through the circle of Willis. © 2018 Colegio Brasileiro de Patologia Animal. All Rights Reserved. RESUMO. Descrevem-se seis casos de tuberculose no sistema nervoso central (SNC) em bovinos, no semiárido da Paraíba. Foram revisados os laudos de um total de 851 necropsias de bovinos realizadas no período de 2003 a 2016. Destes, 73 (8,6%) foram diagnosticados com tuberculose e seis apresentavam lesões no SNC. Três casos ocorreram em bovinos de até dois anos de idade e três em bovinos adultos. Três bovinos apresentaram exclusivamente sinais nervosos, dois tinham sinais respiratórios e perda de peso e um não apresentava nenhum sinal clínico. Macroscopicamente, em cinco bovinos, havia espessamento das leptomeninges do cerebelo, medula espinhal, ponte, obex, colículos e córtex, principalmente, na região basilar encefálica próxima ao polígono de Willis. Em apenas um bovino houve a presença de tubérculo único no cerebelo. Microscopicamente observou-se moderada a acentuada meningite e encefalite granulomatosa. Cinco bovinos apresentaram lesões pulmonares e nos gânglios mediastínicos e três deles tinham lesões disseminadas em outros órgãos. Em todos os bovinos foram encontrados bacilos ácido-álcool resistentes intralesionais e todos tiveram marcação positiva na técnica de imuno-histoquímica com anticorpo policlonal anti-Mycobacterium tuberculosis. Conclui‑se que a tuberculose do sistema nervoso central de bovinos ocorre de forma esporádica na Paraíba, principalmente em bovinos com lesões disseminadas em outros órgãos. Sugere-se que a disseminação do agente ocorre pela via hematógena, possivelmente através do polígono de Willis.
653 $aACID-FAST RESISTANT BACTERIA
653 $aBACTERIOSES
653 $aBRAZIL
653 $aCATTLE
653 $aCENTRAL NERVOUS SYSTEM
653 $aMYCOBACTERIUM SP
653 $aPARAIBA
653 $aPATHOLOGY
653 $aPLATAFORMA SALUD ANIMAL
653 $aTUBERCULOSIS
653 $aZIEHL NEELSEN
700 1 $aNASCIMENTO, E. M.
700 1 $aKONRADT, G.
700 1 $aNETO, E. G. M.
700 1 $aDRIEMEIER, D.
700 1 $aGALIZA, J. N. G.
700 1 $aDANTAS, A. F. M.
700 1 $aRIET-CORREA, F.
773 $tPesquisa Veterinaria Brasileira 38(11):2099-2108, 1 November 2018. OPEN ACCESS
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